Mishale Research

Research & publications

We hold our methods to a falsifiable standard and publish the evidence — including the failures. Our validation benchmark is pre-registered and reported in full at every revision.

Preprint9 June 2026

Retrospective concordance of a deterministic computational pipeline for gene-therapy target feasibility

Wilson Mudaki

A pre-registered evaluation of Mishale's feasibility engine against 69 gene-therapy cases with known outcomes: 66/69 correct disposition (95.7%, 95% CI 88.0–98.5%), recapitulation of a clinical dose-limiting toxicity, zero fabricated genes, and full disclosure of every misclassification.

Read the preprint →

Preprints are technical reports and have not been peer reviewed. For the underlying data or methodology, contact contact@mishale.bio.